1Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China 2Division of Endocrinology, Boston Children’s Hospital, Boston, MA 02215, USA 3Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA *Correspondence to:Junli Liu , Email:liujunli@sjtu.edu.cn Ji Miao , Email:ji.miao@childrens.harvard.edu Suzhen Chen , Email:cszdream@163.com